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Program (PDF)

Luncheon Seminar Information

Luncheon Seminar Program (PDF)
L1 AIRA Matrix Pvt. Ltd. (PDF)
L3 LunaPath Institute of Toxicologic Pathology Co., Ltd. (PDF)
L4 AnaPath Services GmbH (PDF)
L5 Patholytix (Powered by Deciphex)(PDF)

Program

Special Lecture 1
Day1 January 22 (Thu) 16:45 – 17:45
Lecture Hall (2F Large Hall)

Chair: Satoru Takahashi (Nagoya City University)

SL-1
The innovative cancer therapies targeting cancer stromal senescent cells
○ Makoto Nakanishi
Division of Cancer Cell Biology, The Institute of Medical Science, The University of Tokyo
Special Lecture 2
Day2 January 23 (Fri) 13:20 – 14:20
Lecture Hall (2F Large Hall)

Chair: Kiyokazu Ozaki (Setsunan University)
Etsuko Ohta (Eisai Co., Ltd.)

SL-2
Regenerative medicine using genome-edited pluripotent stem cell-derived retinal organoid transplantation
○ Michiko Mandai1,2)
  • 1）Research Center, Kobe City Eye Hospital,
  • 2）RIKEN BDR
Symposium1
NAMs and Toxicologic Pathology: Potential for Next-Generation Evaluation Methods
Day1 January 22 (Thu) 10:15 – 12:15
Lecture Hall (2F Large Hall)

Chair: Takeshi Toyoda (National Institute of Health Sciences)
Shugo Suzuki (Osaka Metropolitan University)

S1-1
Advancing in New Approach Methodologies (NAMs) in safety assessment and expectations for toxicologic pathology
○ Takashi Yamada
Division of Cellular and Molecular Toxicology, Center for Biological Safety and Research, National Institute of Health Sciences
S1-2
Drug discovery applications of lung organoids and future perspectives
○ Yuki Yamamoto
HiLung Inc.
S1-3
Development of organoid-based evaluation assay systems
○ Yoshiaki Maru
Laboratory of Precision Tumor Model Systems, Chiba Cancer Center Research Institute
S1-4
Potential of microphysiological systems as NAMs for in vitro toxicity assessment
○ Hiroshi Kimura
Micro/Nano Technology Center, Tokai University
Symposium2
Can the Virtual Control Groups (VCGs) Be Applied for Toxicologic Pathology Evaluation?
Day1 January 22 (Thu) 13:25 – 15:25
Lecture Hall (2F Large Hall)

Chair: Takeshi Izawa (Osaka Metropolitan University)
Katsuhiro Miyajima (Tokyo University of Agriculture)

S2-1
Can virtual control groups (VCGs) be applied to the toxicologic pathology evaluation? —Overview of VCGs—
○ Gen Sato1,2)
  • 1）VCG Discussion Team, Non-Clinical Evaluation Expert Committee, Drug Evaluation Committee, JPMA,
  • 2）Global Nonclinical Regulatory Affairs, Eisai Co., Ltd.
S2-2
Pathological evaluation in toxicity studies utilizing Virtual Control Groups: current status and challenges
○ Satomi Nishikawa1,2)
  • 1）)VCG Discussion Team, Non-Clinical Evaluation Expert Committee, Drug Evaluation Committee, Japan Pharmaceutical Manufacturers Association (JPMA),
  • 2）Tanabe Pharma Corporation
S2-3
The path towards qualification and regulatory acceptance of Virtual Control Groups (VCGs) —the IHI VICT3R Project
○ Thomas Steger-Hartmann1), Ferran Sanz2), Frank Bringezu3), Inari Soininen4)
  • 1）Bayer AG, Pharmaceuticals,
  • 2）Universitat Pompeu Fabra, Hospital del Mar Research Institute,
  • 3）Merck Healthcare KGaA, Chemical & Preclinical Safety,
  • 4）SYNAPSE Research Management Partners SL
Symposium3
Toxicologic Pathology and Symbol Grounding Problem—What Does It Mean to Understand Pathology and Interpret Findings?
Day2 January 23 (Fri) 10:10 – 12:10
Lecture Hall (2F Large Hall)

Chair: Masako Imaoka (Daiichi Sankyo Co., Ltd.)
Junko Sato (Mediford Coporation)

S3
Toxicologic pathology and symbol grounding problem—what does it mean to understand pathology and interpret findings?
○ Masako Imaoka1), Junko Sato2)
  • 1）Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd.,
  • 2）Mediford Corporation
S3-1
Variety in pathological terminology
○ Kiyokazu Ozaki
Laboratory of Pathology, Faculty of Pharmaceutical Sciences, Setsunan University
S3-2
What does it mean to understand? The significance of human understanding from the view of symbol grounding problem
○ Masachi Osawa
President of Thinking “O”
S3-3
Survey results sharing from Science Subcommittee
○ Atsuko Murai1,2)
  • 1）Pathobiology Group, Safety and Bioscience Research Department, Translational Research Division, Chugai Pharmaceutical Co., Ltd.,
  • 2）Member of the Science Subcommittee, Japanese Society of Toxicologic Pathology
S3-4
The future of toxicologic pathology (The true value connecting through general pathology)
○ Hijiri Iwata
Laboratory of Toxicologic Pathology, LunaPath Co., Ltd.
IATP Maronpot Guest Lecture
Day2 January 23 (Fri) 9:00 – 10:00
Lecture Hall (2F Large Hall)

Chair: Katsuhiko Yoshizawa (Mukogawa Women’s University)
Takeshi Izawa (Osaka Metropolitan University)

IATP
Application of alternative methods and technologies for cancer hazard identification
○ Arun R Pandiri
Leader Molecular Pathology Group, Division of Translational Toxicology, National Institute of Environmental Health Sciences
Workshop
Day1 January 22 (Thu) 9:05 – 10:05
Lecture Hall (2F Large Hall)

Chair: Akihiro Hirata (Gigu University)
Toshio Imai (Central Institute for Experimental Medicine and Life Science)

W1-1*
Mechanism of cytoplasmic inclusion formation involved in acetamide-induced rat hepatocarcinogenesis
○ Yohei Yamagami1,2), Yuji Ishii1), Shinji Takasu1), Meili Soma1), Takeshi Toyoda1), Tomoaki Murakami2), Kumiko Ogawa1,3)
  • 1）Division of Pathology, National Institute of Health Sciences,
  • 2）Laboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology,
  • 3）Department of Toxicology, Hoshi University
W1-2*
Early pulmonary gene expression changes induced by carbon nanotubes and chemical carcinogens in rat lungs
○ Omnia Ahmed1,2,3), Aya Naiki-Ito2), David Alexander1), Satoru Takahashi2), Hiroyuki Tsuda1,2)
  • 1）Nanotoxicology Project, Nagoya City University,
  • 2）Department of Experimental Pathology and Tumor Biology, Nagoya City University,
  • 3）Department of Forensic Medicine and Clinical Toxicology, Aswan University
W1-3*
Regulation of mutant transcripts by nonsense-mediated mRNA decay (NMD) in dogs and mice with the germline APC variants
○ Teruaki Hirota1,2), Sara Shiomi2), Hiroki Sakai1,2,3), Akihiro Hirata1,2,3)
  • 1）Joint Graduate School of Veterinary Science, Gifu University,
  • 2）Laboratory of Veterinary Pathology, Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University,
  • 3）Center for One Medicine Innovative Translational Research (COMIT), Institute for Advanced Study, Gifu University
W1-4*
Size and surface properties of silica particles in endocytosis-mediated cellular responses in murine macrophages
○ Dipankar Chandra Roy, Kenji Ono, Katsumi Fukamachi, Masumi Suzui
Department of Neurotoxicology, Nagoya City University Graduate School of Medical Sciences and Medical School